Ethanolic extract of Salacca zalacca peel reduce IL-1β and apoptosis in high glucose induced zebrafish embryo

Gestational diabetes is a glucose intolerance level first identified during pregnancy. This condition caused by hormone secretion that hinders insulin action from the placenta which resistance will cause hyperglycemia. increase oxidative stress, and in consequence increasing inflammation cell death can hinder fetal growth development. Salacca zalacca peel food waste contains antioxidants anti-inflammatory properties. research aimed to study effect of SZ ethanolic extract expression IL-1β marker (BAX Apaf-1) 3% induced zebrafish embryo. Glucose metabolism measured Phosphoenolpyruvate carboxykinase (PEPCK) at age 3 dpf. The PEPCK, IL-1β, Bax, Apaf-1 using reverse transcriptase PCR (RT-PCR) method. given concentration 0,1; 0,2; 0,4 mg/mL. result this proves PEPCK decreases group was 3%. significantly Bax mg/mL, also able decrease with most closely resemble negative control In conclusion, protects gestational through Apaf-1.